By Bernard V. Perbal (Editor), Masaharu Takigawa (Editor)
CCN Protein: a brand new family members of mobile development and Differentiation Regulators provides the newest growth within the box of CCN proteins, a brand new kinfolk of secretory signaling molecules which are excited about a number of basic organic growth. those proteins percentage a different multimodular association and current a partial identification with 4 households of regulatory proteins controling progress and improvement. The ebook covers the jobs of CCN proteins within the keep an eye on of phone proliferation and differentiation in the course of general improvement, wound fix, chondrogenesis and bone improvement, angiogenesis, tissue regeneration, fibrosis, renal illnesses and melanoma improvement.
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Extra info for CCN Proteins: A New Family of Cell Growth and Differentiation Regulators
2000). It is noteworthy that the tumors listed in Table 1 have something to do with the expression and function of CCN2 that we have mentioned in this chapter. , 1998). , 1999) reported are also ﬁbrous types. , 2003). Therefore, the overexpression of CCN2 in these tumors might be only a secondary outcome after tumorigenesis. , 2003b) in several types of malignant tumors. Because hypertrophic chondrocytes, which show the highest expression of CCN2 in the physiological state, are fated for death, forced overexpression may cause growth arrest or apoptosis.
These results suggest that CCN2 is involved in not only endochondral but also intramembranous ossiﬁcation and plays important roles in regeneration of bone during distraction osteogenesis (Fig. 2). , 2003). , 1998). The gene was expressed in hypertrophic chondrocytes in the restored cartilaginous skeleton. 2. , 2002). , 2004). , 2004). , 2004). Therefore, CCN2 was suspected to play critical roles in cartilage regeneration. , 2004). , 2004) (Fig. 3). These ﬁndings suggest the utility of CCN2 in the regeneration of articular cartilage.
2. ROLES OF CCN2 IN GROWTH CONTROL It is no exaggeration to say that growth control of vertebrates is highly dependent on the growth control of the skeletal tissues. During skeletal growth, coordinate blood vessel formation also occurs. Therefore, the roles of CCN2 in skeletal growth and angiogenesis are ﬁrstly and secondly, respectively, described in this section. The role of CCN2 in other cells and tissues is mentioned lastly. 1. Roles of CCN2 in Skeletal Growth Bone is formed by 2 pathways (Fig.
CCN Proteins: A New Family of Cell Growth and Differentiation Regulators by Bernard V. Perbal (Editor), Masaharu Takigawa (Editor)