New PDF release: Aging. Modern theories and therapies

By Joseph Panno

ISBN-10: 0816068461

ISBN-13: 9780816068463

Makes an attempt to appreciate the getting older technique have generated a good number of theories yet few functional treatments. conventional cures deal with age-related ailments comparable to melanoma and arthritis yet don't opposite the getting older technique itself. a typical development in gerontology is to look for genes that experience a demonstrable influence on lifespan, the so-called toughness genes. Many such genes were pointed out, and even though the manipulation of those genes doesn't cease the getting older procedure, they supply many helpful insights into the mobile mechanisms of getting older. extra lately, curiosity has grew to become to using cloning expertise, stem mobile research, and genetic manipulation which will produce a good rejuvenation remedy for cells and the physique as an entire.

getting older, Revised version describes the sphere of gerontology and the numerous theories that scientists have built through the years to give an explanation for the age-related adjustments that take place in approximately all animals.

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Additional info for Aging. Modern theories and therapies

Sample text

Unfortunately, this convention is confusing since “normal” often implies healthy. In the discussion that follows, aging in the absence of disease will be referred to as classical aging, and aging that is associated with disease will be called modern aging. Classical Aging Classical aging may be characterized as a gradual reduction in the functional capacity of the individual without the onset of severe disabilities. People who age in this way remain physically active well into their 80s and 90s.

Caloric restriction has the same effect, but is most likely due to the forced reduction in flight activity, due to a lack of energy. Raising mice or rats in confined quarters to lower their activity level has no effect and may even reduce the life span because of the stress that it causes in these animals. Caloric restriction, however, can increase a rat’s life span by 50 to 60 percent. Researchers at the University of Wisconsin, led by Drs. Ricki Colman and Richard Weindruch, have recently completed a 20year experiment in which rhesus monkeys were raised on a lowcalorie diet (30 percent fewer calories per day).

Or is aging the unfortunate side effect of adaptations that make it possible for us to have and protect our offspring? Many gerontologists believe that aging is a matter of evolutionary neglect, rather than design. However life spans evolved, it is clear that our genes have the final say in how long an individual will be on the stage. Even though flies and humans are constructed from the same kinds of cells (eukaryotes), one animal lives two weeks, the other 80 years. If those eukaryotes had remained free-living, as their protozoan ancestors have done, they would live for millions of years.

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Aging. Modern theories and therapies by Joseph Panno

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